Anti-nuclear activists have arrived at Parliament House in Canberra, after walking more than 2,000 kilometres from the Roxby Downs uranium mine in South Australia.

Aboriginal elder 'Speedy' McGuiness and activist William Taylor are calling for an end to uranium mining in Australia.

After arriving in Canberra, an emotional Mr Taylor described how he had heard many stories about the effects of uranium mining on small communities.

"We're haunted by the stories and the people we meet, who are compelled to try and make some sense of this," Mr Taylor said.

"When governments don't send up for us, then [we must] stand up and do it ourselves."